The Interoceanic Highway or Trans-oceanic highway is an international, transcontinental highway in Peru and Brazil that connects the two countries. It was completed in 2011, and runs east to west, spanning 2,600 kilometres (1,600 mi).

From Peru's Pacific Ocean coastline, it continues across the Andes mountains and through a large part of the Amazon rainforest in the Peruvian department of Madre de Dios. It then travels into Northwestern Brazil where it connects with a network of existing highways to the Atlantic. Thus, passing by the regionally important cities of Cusco, Cobija and Rio Branco. It entailed the renovation and construction of roughly 2,600 kilometers of roads and 22 bridges. Completed in 2011, it creates a connected highway from the Peruvian ports of San Juan de Marcona to the Brazilian city of Rio Branco its ZPE (Special Export Zone) and the rest of the country. The project came into being via a 2004 agreement between Alejandro Toledo and Luiz Inácio Lula da Silva, then presidents of the two countries.

In Peru the project is known by the MTC (Ministerio de Transportes y Comunicaciones) as the Corredor Vial Interoceánico Sur Perú-Brasil and by ProInversion (Private Investment Promotion Agency - Peru) as the Initiative for the Integration of the Regional Infrastructure of South America, (Iniciativa para la Integración de la Infraestructura Regional Suramericana) (IIRSA), SUR axis. The project is part of a national road investment plan which involves the construction of three longitudinal highways, and 20 transversal highways. Parts of these transversal highways make up part of IIRSA SUR.